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Biomedical Reviews

Biological functions of lysosomal membrane-associated glycoproteins

Victoria Sarafian, Michel Jadot, Simone Wattiaux-De Coninck, Robert Wattiaux

Abstract

Lysosomes are the final repository of degradation products from the extracellular and intracellular spaces. The lysosomal membrane forms a unique vacuole participating in both endocytosis and autophagocytosis. It is extremely resistant to degradation by lysosomal hydrolases, maintains an acidic intralysosomal environment, transports amino acids and oligosaccharides produced by lysosomal hydrolases, interacts and fuses with other membrane organelles, such as endosomes and phagosomes, and with the plasma membrane.

Biomedical Reviews 1997; 8: 119-125.


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DOI: http://dx.doi.org/10.14748/bmr.v8.155

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About The Authors

Victoria Sarafian
Medical University of Plovdiv
Bulgaria

Michel Jadot
University of Namur
Belgium

Simone Wattiaux-De Coninck
University of Namur
Belgium

Robert Wattiaux
University of Namur
Belgium

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