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Management of health risk related to use of engineered nanomaterials. An analogy with biosafety

Dimiter Prodanov


Safety of nanomaterials is a new scientific field, which draws increasing attention in literature. Among the challenges the field is facing are the insufficient amount and quality of nanotoxicological data and the ambiguity in the metrics describing the exposure. This results in substantial difficulties in the actual quantification of risk in terms of dose-response relationships and exposure limits, which is a cornerstone of chemical risk assessment. While there is no golden standard for risk assessment and management several pragmatic systems have come into being. All of these employ some form of categorization and grouping of materials into hazard groups. The present review aims to draw analogies between the nascent field of nanosafety and the well established field of biosafety, where the risk is also difficult to quantify. Biomed Rev 2017; 28:100-104.

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ANSES. Development of a Specific Control Banding Tool for Nanomaterials. 2010.

ANSES. Assessment of the risks associated with nanomaterials: Issues and update of current knowledge. 2014.

Brouwer D, van Duuren-Stuurman B, Berges M, Jankowska E, Bard D, Mark D. From workplace air measurement results toward estimates of exposure? Development of a strategy to assess exposure to manufactured nano-objects, J Nanopart Res 2009; 11, 1867. DOI: 10.1007/s11051-009-9772-1.

Brouwer D. Control banding approaches for nanomaterials, Ann Occup Hyg 2012; DOI: 10.1093/annhyg/mes039.

Corlan D. Medline trend: automated yearly statistics of PubMed results for any query. 2004. Web resource at URL:

Dekkers S, Oomen AG, Bleeker EA, Vandebriel RJ, Micheletti C, Cabellos J, et al. Towards a nanospecific approach for risk assessment. Regul Toxicol Pharmacol 2016; 80: 46-59. DOI: 10.1016/j.yrtph.2016.05.037.

Duuren-Stuurman BV, Vink SR, Verbist KJM, Brouwer HGAHDH, Kroese DED, Niftrik MFJV, et al. Stoffenmanager Nano Version 1.0: A Web-Based Tool for Risk Prioritization of Airborne Manufactured Nano Objects. Ann Occup Hyg 2012; DOI: 10.1093/annhyg/mer113.

Hristozov D, Gottardo S, Semenzin E, Oomen A, Bos P, Peijnenburg W, et al. Frameworks and tools for risk assessment of manufactured nanomaterials, Envir Int 2016; 95: 36-53. DOI: 10.1016/j.envint.2016.07.016.

NIOSH. Approaches to Safe Nanotechnology. Managing the Health and Safety Concerns Associated with Engineered Nanomaterials, DHHS (NIOSH) Publication No. 2009–125, 2009.

Paik U, Park J-G. Nanoparticle engineering for chemical-mechanical planarization: Fabrication of next-generation nanodevices. CRC Press 2009.

Savloaainen K, et al. Towards safe and sustainable nanomaterials and nanotechnology innovations, Finnish Inst Occup Health (Helsinki) 2013. DOI: 10.13140/2.1.3084.8969.

Van Hoornick N, Prodanov D, Pardon A. Banding approach for engineered nanomaterial risk assessment and control. J Phys: Conference Series 2017; 838: 012017. DOI: 10.1088/1742-6596/838/1/012017.

Laboratory Biosafety Manual, WHO 2004.



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Dimiter Prodanov
Environment, Health and Safety, Imec

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