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RME-based pharmacology: The inhibition of viral entry as therapeutic perspective in viral diseases including AIDS. Hypothesis updated and enlarged

George N. Chaldakov, Stanislav Yanev


In 1990, one of us (GNC) for the first time reported a hypothesis of receptor-mediated endocytosis (RME)-based pharmacology relevant to the possible antiviral therapy including in acquired immunodeficiency syndrome (AIDS). Then, RME using clathrin-coated pits/vesicles was the best-characterized endocytic pathway. Since then now, intensive research on the mechanisms of both RME and receptor-mediated virus-cell fusion (receptor-mediated fusion - RMF) helped to expand the list of chemical compounds with potential clinical application as antiviral agents, the so-called entry inhibitors, e.g. (i) inhibitors of clathrin-, dynamin-2-, caveolin- and/or lipid rafts-dependent RME, and (ii) inhibitors of RMF. Accordingly, in the present Dance Round we update and enlarge our hypothesis of RME-based antiviral pharmacology.


receptor-mediated endocytosis, receptor-mediated fusion, clathrin, caveolin, dynamin-2, lipid rafts, viruses, HIV-1, AIDS, therapy

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About The Authors

George N. Chaldakov
Medical University of Varna

Department of Anatomy and Cell Biology

Stanislav Yanev
Bulgarian Academy of Sciences, Sofia, Bulgaria

Laboratory of Drug Toxicology, Institute of Neurobiology

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