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Bulgarian Review of Ophthalmology

Optical Coherent Tomography changes in retinal nerve fiber layer and ganglion cell complex in different stages of open-angle glaucoma

S. Kostianeva, A. Gerdzhikov, M. Konareva-Kostianeva, M. Atanasov

Abstract

Purpose: To evaluate the quantitative measurements of ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (RNFL) obtained by optical coherent tomography (OCT) in different stages of open-angle glaucoma.

Methods: Sixty eyes of 34 patients with open-angle glaucoma and 60 eyes of 30 healthy people are examined using RTV-ue 100 (Optovue Inc., Fremont, CA). According to visual field global indices MD and PSD (Humphrey Analyzer) glaucomatous eyes are separated into two groups: 33 eyes with early glaucoma and 27 eyes with advanced glaucoma. GCC and RNFL (using two scanning protocols of RTV-ue - ONH and RNFL 3.45) are analyzed in all of the eyes included in the study.

Results: GCC average is with highest values in normal eyes, followed by the glaucomatous eyes in early stage and glaucomatous eyes in advanced stage (96.7±5.3ô€‚— versus 81.0±9.4ô€‚— versus 75.0±16.8ô€‚—). Concerning the indices GCC average, GCC superior and GCC inferior in eyes with early and advanced glaucoma statistically significant difference is not found (respectively P=0.081, P=1.00, P=0.335). However, the thickness of the peripapillary nerve fiber layer, measured by the two scanning protocols, is statistically significantly different in early and advanced glaucoma (p<0.001).

Conclusion: Our results show that measurement of the peripapillary RNFL is more reliable OCT indicator for follow-up of glaucoma progression.


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DOI: http://dx.doi.org/10.14748/bro.v0i2.5231

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About The Authors

S. Kostianeva
Dept. Ophthalmology, Medical University, Plovdiv
Bulgaria

A. Gerdzhikov
Dept. Ophthalmology, Medical University, Plovdiv
Bulgaria

M. Konareva-Kostianeva
Dept. Ophthalmology, Medical University, Plovdiv
Bulgaria

M. Atanasov
Dept. Ophthalmology, Medical University, Plovdiv
Bulgaria

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