Scientific Online Resource System

Heart - Lung (Varna)

Sarcoidosis - Possible diagnosis or utter surprise?

Darina Ivanova, Boyan Balev


Sarcoidosis is a multisystemic inflammatory disorder with unknown etiology. Its main characteristic is the formation of noncaseous epithelioid cell granulomas in the affected organs.
It is a systemic disease, but thoracic involvement is present in over 90% of cases. Although chest radiography is often the first method of choice in patients with pulmonary involvement, computed tomography (CT) and high resolution CT (HRCT) in particular are more sensitive for the detection of thoracic adenopathy and subtle changes in lung parenchyma.

Pulmonary sarcoidosis may manifest with various radiologic patterns. To achieve a timely diagnosis and help reduce associated morbidity and mortality, it is essential to recognize both the typical and the atypical clinico-radiological manifestations of the disease.

The aim of this presentation is to analyze and demonstrate both the typical and atypical CT changes found in 20 patients with histologically proven sarcoidosis. The presented data will also be supported by a brief review of literature.

Full Text


Wolfgang Dahnert, M.D, Radiology Review Manual 7th edition,.

Галина Кирова, Образна диагностика на заболяванията на гръдния кош 2005

Criado E., Sanchez M., Ramirez J et al., Pulmonary Sarcoidosis: Typical and Atypical Manifestations at High-Resolution CT with Pathologic Correlation, October 2010 RadioGraphics,30, 1567-1586.

Verschakelen J.A., Sarcoidosis: imaging features, Eur Respir Mon, 2005, 32, 265–283

Mafia J, Teirstein A.S, Mendelson D.S. et al.,Excessive thoracic computed tomographic scanning in sarcoidosis, Thorax 1995;50:1264-1266

Abehsera M, Valeyre D, Grenier Ph. et al., Sarcoidosis with Pulmonary Fibrosis: CT Patterns and Correlation with Pulmonary Function

Park H.J. ,Jung J.I.,Chung M.H. et al., Typical and Atypical Manifestations of Intrathoracic Sarcoidosis, Korean J Radiol 2009;10:623-631

van de Laaр М., Schäfer V., Schett G., Eular On-line Course on Rheumatic Diseases – module n°10

Baughman RP, Teirstein AS, Judson MA, et al, . Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med2001;164:1885–188

Neville E, Walker AN, James DG, . Prognostic factors predicting the outcome of sarcoidosis: an analysis of 818 patients. Q J Med 1983;52(208):525–533.

Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 1999;160(2):736–755.

Herráez Ortega I1, Alonso Orcajo N, López González L, The "sarcoid cluster sign". A new sign in high resolution chest CT,. , Radiologia. 2009 Sep-Oct;51(5):495-9. doi: 10.1016/j.rx.2009.05.003. Epub 2009 Sep 10



Font Size