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Cardiovascular architectural changes in patients with chronic kidney disease with secondary hyperparathyroidism

Svetla Staykova


Cardiovascular diseases (CVD) are common in patients with chronic renal failure and are the leading cause of morbidity and mortality in patients on dialysis treatment. The CVD score is higher in patients with chronic kidney disease (CKD) (5th stage), where mortality reaches almost 100 times that of the general population.
Approximately 80% of the patients on dialysis have left ventricular hypertrophy (LVH) even before extracorporeal treatment is started. LVH is an adaptive process that develops as a result of increased heart rate due to continuous and excessively increased pressure (increased overload) and bulk load (increased overload). Deepening of anemic syndrome, uncontrolled arterial hypertension, proven diabetes mellitus and secondary hyperparathyroidism are widespread in patients with CKD.
Initially, arterial calcification was described as passive deposition of amorphous material under conditions of hyperphosphatemia and transient increases in calcium levels recorded during CKD.


cardiovascular risk; CKD; calcifications; hyperphosphatemia

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