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Biomarkers in paroxysmal atrial fibrillation

M. Negreva, A. Penev


In recent decades the incidence of atrial fibrillation (AF) has increased significantly due to various reasons such as aging, improved  therapy  and higher survival rates of patients with cardiovascular diseases. AF is associated with higher mortality rate, larger number of hospitalizations, lower quality of life and increased mortality. Therefore, the discovery of biomarkers of the pathological mechanisms responsible for the occurrence of arrhythmia and following complications will have a wide clinical application.


atrial fibrillation; biomarkers; inflammation; neurohormonal activation; endothelial dysfunction; oxidative stress

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Anderson, J. L., A. Maycock, D. L. Lappé, et al. Fre- quency of elevation of C-reactive protein in atrial fibrilla- tion. Am J Cardiol 2004;94:1255-9.

Benjamin, E. J., P.A. Wolf, R. B. D`Agostino et al. Im- pact of atrial fibrillation on the risk of death: the Framing- ham Heart Study. Circulation. 1998;98:946-952

Carnes, C.A., P. M. Janssen, M. L. Ruehr et al. Atrial glutathione content, calcium current, and contractility. J Biol Chem. 2007;282(38):28063-73.

Dernellis, J., M. Paraneu. C-reactive protein and par- oxysmal atrial fibrillation: evidence of the implication of an inflammatory process in paroxysmal atrial fibrillation. Acta Cardiol. 2001;56(6):375-80.

Dudley, S. C., N. E. Hoch, L. A. McCann et al. Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases. Circulation. 2005 ;112(9):1266-73.

Ellinor, P. T., A. F. Low, K. Kristen K. Et al. Discord- ant atrial natriuretic peptide and brain natriuretic pep- tide levels in lone atrial fibrillation. J Am Coll Cardiol. 2005;45(1):82-86.

Friberg, J., P. Buch , H. Scharling et al. Rising rates of hospital admissions for atrial fibrillation. Epidemiology 2003;14: 666-672.

Fu, R., S. Wu, P. Wu et al. A Study of blood soluble P-selectin, fibrinogen, and von Willebrand factor lev- els in idiopathic and lone atrial fibrillation. Europace 2011;13:31-36.

Gabay, C., I. Kushner. Acute phase proteins and oth- er systemic responses to inflammation. N Engl J Med 1999;340:448 -54.

Issac, T. T., H. Dokainish, N. M. Lakkis. Role of In- flammation in Initiation and Perpetuation of Atrial Fibril- lation: A Systematic Review of the Published Data. Am

Coll Cardiol. 2007;50(21).

Lenaerts, I., R. B. Driesen, N. H. Blanco et al.Role of nitric oxide and oxidative stress in a sheep model of per- sistent atrial fibrillation. Europace;15(5):754-60.

Levin, E. R., D. G. Gardner, W. K. Samson, WK

.Natriuretic peptides. N Engl J Med 1998;339: 321-32.

Li-Saw-Hee, F. L., A. D. Blann, D. Gurney at al. Plas- ma von Willebrand factor, fibrinogen and soluble P-selec- tin levels in paroxysmal, persistent and permanent atrial fibrillation. European Heart Journal 2001;22: 1741-1747.

Marsiliani, D., F. Buccelletti, A. Carroccia et al. Euro- pean Review for Medical and Pharmacological Sciences. Natriuretic peptides and atrial fibrillation 2010; 14: 855- 860

McEver R. P. Properties of GMP-140, an inducible granule membrane protein of platelets and endothelium Blood Cells 1990;16:73-83.

Mihm, M. J., F. Yu, C. A. Carneset al. Impaired myofi- brillar energetics and oxidative injury during human atrial fibrillation. Circulation. 2001;104(2):174-80.

Ommen, S., J. Odell, M. Stanton. Atrial arrhythmias after cardiothoracic surgery. N Engl J Med 1997;336:1429


Reynolds, M. R., T. Lavelle , V. Essebag et al. Influ- ence of age, sex, and atrial fibrillation recurrence on qual- ity of life outcomes in a population of patients with new- onset atrial fibrillation: the Fibrillation Registry Assessing Costs, Therapies, Adverse events and Lifestyle (FRAC- TAL) study. Am Heart J. 2006;152:1097-1103.

Ridker, P. M., E. Julie. Buring and Nader RifaiSoluble P-Selectin and the Risk of Future Cardiovascular Events. Circulation. 2001;103:491-495.

Sata, N., N. Hamada, T. Horinouchi et al. C-reac- tive protein and atrial fibrillation: Is inflammation a consequence or cause of atrial fibrillation? Jpn Heart J 2004;45:441-5.

Sohara, H., S. Amitani, M. Kurose et al. Atrial Fi- brillation Activates Platelets and Coagulation in a Time- Dependent Manner: A Study in Patients With Paroxysmal Atrial Fibrillation. J Am Coll Cardiol. 1997;29(1):106- 112.

Stewart, M. E., G. Lowe, J. T. Douglas et al. PROG- NOSTIC VALUE OF BETA-THROMBOGLOBULIN IN PATIENTS WITH TRANSIENT CEREBRAL ISCHAE- MIA. The Lancet 1983; 322(8348):479-48.

Stewart, S., C.L. Hart , D.J. Hole et al. Population prevalence, incidence, and predictors of atrial fibrillation

in the Renfrew/Paisley study. Heart. 2001;86:516-521.

Tsuchida, K., K. Tanabe. Influence of paroxysmal atri- al fibrillation attack on brain natriuretic peptide secretion. J Cardiol. 2004 ;44(1):1-11.

Vischer, U. M. von Willebrand factor, endothelial dys- function, and cardiovascular disease. J Thromb Haemost. 2006 ;4(6):1186-93

Wożakowska-Kapłon, B. Effect of sinus rhythm resto- ration on plasma brain natriuretic peptide in patients with atrial fibrillation The American Journal of Cardiology 2004;93(12):1555-1558.



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