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Upstream therapy in atrial fibrillation

A. Kisheva, Y. Yotov, A. Angelov, A. Penev


atrial fibrillation (aF) is the most common rhythm disorder and a frequent cause for hospitalization and increased mortality and morbidity. the conventional antiarrhythmic therapy has limited options for prevention of aF, so other ways of prevention are being researched. the so-called upstream therapy is being studied for possible beneficial effects and was included in some guidelines of conduct in Europe and worldwide. In this review we indicate the evidence for the effects of different drug classes for primary and secondary prevention of aF. We discuss the action of the inhibitors of the renin-angiotensin system, aldosterone receptors blockers, antilipemic and antioxidant agents and other impact options.


atrial fibrillation; prevention; upstream therapy

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