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Journal of the Union of Scientists - Varna. Medicine and Ecology Series

Whipple’s disease – the challenge of the clinical imitator

Diana Todorova Gancheva-Tomova

Abstract

Whipple’s disease is a rare systemic infectious disease caused by the bacterium Tropheryma whipplei. It affects many organs and systems. The disease is still difficult to diagnose because of the variety of clinical symptoms and the possible long period between the first uncharacteristic signs and the complete clinical picture of the disease. Because the clinical symptoms of the disease are nonspecific, the diagnosis is still a challenge for the clinician. The outcome is fatal in the absence or failure of antibiotic treatment. We present a brief review of the literature on the clinical picture, the diagnostic possibilities, and the treatment of Whipple's disease.

Keywords

Whipple’s disease, clinical manifestations, diagnosis, treatment

Full Text


References

Al-hamoudi, W, Habbab F, Nudo C, Nahal A, Flegel K. Eosinophilic vasculitis: A rare presentation of Whipple’s disease. Can J Gastroenterol, 21, 2007, No 3, 189-191.

Bures J, Kopacova M, Douda T, Bartova J, Toms J, Reichrt S, et al. Whipple’s Disease: Our Own Experience and Review of the literature. Gastroenterology Research and Practice, 2013, 2013. http://dx.doi.org/10.1155/2013/478349.

Chhabria MA, Dalal RL, Desai DC, Deshapande RB. Whipple’s disease. J Assoc Physicians India, 58, 2010, 196-197.

Conly JM, Johnston BL. Rare but not so rare: The evolving spectrum of Whipple’s disease. Can J Infect Dis, 12, 2001, No 3, 133-135.

Desnues B, Ihrig M, Raoult D, Mege JL. Whipple’s Disease: a Macrophage Disease. Clin Vaccine Immunol, 13, 2006, No 2, 170-178.

Discovery of first genetic cause of Whipple’s disease. Inserm, French National Institute of Health and Medical Research. Newsroom Partager Chercher. https://presse.inserm.fr/en/discovery-of-a-first-genetic cause-of-whipples-disease/31198/.

Fenollar F, Mediannikov O, Socolovschi C, Bassene H, Diatta G, Richet H, et al. Tropheryma whipplei Bacteremia during Fever in Rural West Africa. Clin. Infect. Dis., 51, 2010, № 5, 515-521.

Fenollar F., Puechal X, Raoult D. Whipple’s Disease. N Engl J Med, 356, 2007, No 1, 55-66.

Greub G. A New Piece Added to the Whipple Puzzle: Tropheryma whipplei Primary Infection with Bacteremia and Cough. Clin Infect Dis, 51, 2010, No 5, 522-524.

Günther U, Moos V, Offenmüller G, Oelkers G, Heise W, A Moter A, et al. Gastrointestinal Diagnosis of Classical Whipple Disease: Clinical, Endoscopic, and Histopathologic Features in 191 Patients. Medicine, 94, 2015, No 15. DOI: 10.1097/MD.0000000000000714.

Hashim H, Ahmed S, Shami S, Saeed I. Whipple’s disease of the appendix. J R Soc Med, 94, 2001, No 12, 643-644.

Kramer LC, Manschot TAJM, Barendregt JNM, Smit JM. Whipple’s disease: often a late diagnosis and a rare cause of nephropathy. NDT Plus,2, 2009, No 1, 55-58.

Misbah SA, Ozols B, Franks A, Mapstone N. Whipple’s disease without malabsorption: new atypical features. Q J Med, 90, 1997, No 12, 765-772.

Muir- Padilla MAJ., Myers CJB. Whipple Disease. A Case Report and Review of Literature. Arch Pathol Lab Med, 129, 2005, No 7, 933-936.

Renon V P, Appel-da-Silva MC, D’Incao RB, Lul RM, Kirschnick LS, Galperim B. Whipple’s disease: rare disorder and late diagnosis. Rev Inst Med Trop Sao Paolo, 54, 2012, No 5, 293-297.

Roberts IM. Whipple Disease. Updayed: Nov 20, 2016. http://emedicine.medscape.com/article/183350-overview.

Schijf LJ, Becx MCJM, de Bruin PC, van der Vegt SGL. Whipple’s disease: easily diagnosed, if considered. Neth J Med, 66, 2008, No 9, 392-395.

Sharma OP. Beethoven’s illness: Whipple’s disease rather than sarcoidosis? J R Soc Med,87, 1994, No 5, 283-285.

Urbanski G, Rivereau P, Artu L, Fenollar F, Raoult D, Puechal X. Whipple Disease Revealed by Lung Involvement. Chest, 141, 2012, No 6, 1595-1598.

Villa A, Nucera G, Kostihova A, Mazzola A, Marino P. Reversible Pulmonary Hypertension Associated with Whipple’s Disease. Case Reports in Pulmonology, 2012, 2012, doi: 10.1155/2012/382460.




DOI: http://dx.doi.org/10.14748/isuvsme.v23i1.5540

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