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Journal of the Union of Scientists - Varna. Medicine and Ecology Series

Pleomorphic adenoma – morphological characteristics

George St. Stoyanov, Ina Kobakova, Lyuben Stoev



Pleomorphic adenoma or tumor mixtus (mixed tumor) is the most common benign tumor of the salivary glands accounting for up to 75% of all salivary gland tumors. The tumor is a smooth, lobular and encapsulated formation.


The purpose of this study was to investigate in detail 30 cases of surgically removed pleomorphic adenomas and to analyze the morphological features and other variables such as age and sex of the patients and tumor size.


The results of the study showed a tendency for morphological diversity depending on the gender and age of the patients. In 15 of the cases, we observed small round focuses on well-defined tumor tissue located near the capsule of the main lesion, described in the literature as microsatellites.


The results indicate that morphological differences of pleomorphic adenoma (especially the presence of microsatellites) can lead to a variety of clinical presentations and are key to the biological behavior.


pleomorphic adenoma; salivary gland tumors; morphological diagnostics; clinical and morphological analysis

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