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Journal of the Union of Scientists - Varna. Medicine and Ecology Series

Saliva as a primary biological marker

Christiana Madjova



Saliva is the main biological oral environment in which the oral cavity processes take place. Its presence has a role in maintaining healthy oral tissues and protecting dental tissues.


The aim is to make an up-to-date reading of the studies of Bulgarian and foreign authors and to summarize the data from scientific literature and from own researches in order to reveal the clinical potential of saliva for its full use.

Materials and Methods:

In Google scholar, Web of Science, PubMed, Scopus and ScienceDirect a search is conducted for a period of 31 years. The keywords are: "saliva", "research", "biological marker", "oral health".


Saliva has many advantages - one of the largest is the presence therein of substances that come from the gingival fluid, and the local blood flow of the salivary glands. Therefore changes in its components are proportional to those in the blood serum. It is the most affordable and non-invasive biofluid the human body. Saliva offers many advantages as a diagnostic fluid - it can easily be assembled, no special device or device is required and it contains serum components.


Saliva has clinical potential for its full use in many areas of medicine. This is the future development of dental science - good synergy and cooperation between it and medicine. This will improve not only the oral but also the general health of the people.


saliva, biological marker, research, oral pathology, oral health

Full Text


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