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Influence of Fruit Juice From Aronia Melanocarpa on the Process of Lipid Peroxidation in a Model of Carbon Tetrachloride-Induced Hepatotoxicity in Rats

S. Valcheva-Kuzmanova, B. Galunska, P. Borisova, T. Yankova, A. Belcheva

Abstract

The fruit juice from Aronia melanocarpa (FJAM) is rich in anthocyanins. We studied the effect of FJAM on the process of lipid peroxidation in a model of carbon tetrachloride (CCI4)-induced hepatotoxicity in rats. Malondialdehyde (MDA) levels were measured in plasma and liver homogenate. CCU induced a significant elevation of MDA levels in the plasma (p<0,05) and in the homogenate (p<0,01) in comparison with distilled water-treated controls. FJAM applied alone did not significantly influence on the MDA levels. The pretreatment of the rats with FJAM before their treatment with CCI4 lead dose-dependently to MDA levels in the plasma and homogenate which did not differ in most animal groups from the controls and were significantly lower from those of the CCI4-treated rats.


Keywords

Aronia Melanocarpa; Phytotherapy; Lipid Peroxidation; Carbon Tetrachloride; Malondialdehyde

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DOI: http://dx.doi.org/10.14748/ssm.v35i0.1949

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About The Authors

S. Valcheva-Kuzmanova

Bulgaria

S. Valcheva-Kuzmanova, Dept. of Preclinical and Clinical Pharmacology and Biochemistry, Prof. P. Stoyanov Medical University of Varna, 55 Marin Drinov St, BG-9002 Varna
BULGARIA
E-mail: pharmacol@asclep.muvar.acad.bg

B. Galunska

Bulgaria

P. Borisova

Bulgaria

T. Yankova

Bulgaria

A. Belcheva

Bulgaria

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