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Scripta Scientifica Medica

Structural and functional integration between nervous system and immune system

W. Ovtscharoff

Abstract

In the last decades were established extensive bidirectional functional and structural communications between nervous and immune system. Neuromediators, cytokines and trophic factors take part in the cell signaling in both systems.The structural interaction occurs by means of sensory and postganglionic sympathetic and parasympathetic fibers. They enter in the lymphoid tissue and organs. In this way is formed the bidirectional interaction between nervous and immune system. This communication exists in health and diseases. The neurotransmitters derived from the nerve fibers regulate the activity of the immune cells by means of their membrane receptors. It is known that T cell-derived cytokines activate and modulate the function of other cells of the immune system. These cytokines influence the activity of the neurons and glial cell in several brain areas as they have membrane cytokine receptors.In the interaction between nervous and immune system has an important role the hypothalamo-pituitary-adrenal axis using glucocorticoids.




DOI: http://dx.doi.org/10.14748/ssm.v48i0.2307

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W. Ovtscharoff

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