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Scripta Scientifica Medica

POSSIBILITIES FOR EXPANDING THE INDICATIONS FOR CHEMOTHERAPY OF UTERINE CANCER

Zh. Georgieva, K. Nenova, H. Tsekov, D. Mazhdrakova

Abstract

Incidence rate of myocardial dysfunction in females operated on the occasion of uterine cancer and with manifestations of symptomatic chronic iron-deficiency anemia (IDA) of moderate or severe degree was studied. A diagnostic test for early diagnosis and dynamic monitoring of the left-ventricular dysfunction aiming at enlarging the chemotherapeutic indications was suggested. The left ventricular dysfunction registered according to echocardiographic criteria in 56 patients with uterine cancer and IDA required correction of the chronic anemic hypoxia prior to chemotherapy. Echocardiographically, there was a reversibility of left ventricular volume loading in 82 per cent of the cases (p < 0,001) after anemia correction. Chemotherapy administration was enabled after achieving the definite values of left ventricular dimension using a dynamic echocardiographic control. The early diagnosis of the myocardial dysfunction and its timely correction allowed not only the optimization of the chemotherapy but also the expansion of its indications.


Keywords

iron deficiency anemia; uterine cancer; myocardial dysfunction; left ventricular monitoring; echocardiography

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DOI: http://dx.doi.org/10.14748/ssm.v32i0.2759

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About The Authors

Zh. Georgieva

K. Nenova

H. Tsekov

D. Mazhdrakova

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