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M. Nenova, D. Nikolova


The considerable epidemic potential of Shigelloses in extreme situations determines their socio-medical significance and therapeutic challenge. In the First Infectious Clinic, Department of Infectious Diseases and Epidemiology, Medical University of Varna, 30 patients aged between 18 and 51 years were administered ciprofloxacine at a dose of 500 mg twice daily for one day only. Their mean hospital stay was 7,48 ± 1,27 days long. The control group consisted of 24 age-matched patients treated with other chemotherapeutic drugs for 3-5 days which mean hospitalization was 8,04 ± 2,99 days long. In 27 ciprofloxacine-treated patients the clinical healing occurred on the third hospital day. The febrility disappeared and the stools normalized. The pathological  admixtures of mucus and blood disappeared until the third day. The authors conclude that the one-day treatment of shigellosis with ciprofloxacine is safe and effective. The short duration of the therapy reduces the isolation period. No side effects are observed at all.


Shigellosis; ciprofloxacine, one-day treatment; Shigella sensitivity; duration of hospitalization

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M. Nenova

D. Nikolova

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