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Scripta Scientifica Medica

ANTIBODIES DIRECTED TO INDIVIDUAL HISTONES IN JUVENILE CHRONIC ARTHRITIS. ASSOCIATION WITH UVEITIS

B. Varbanova, M. Baleva, K. Nikolov

Abstract

The trials for identification of the specific target antigen for antinuclear antibodies (ANA) in juvenile chronic arthritis (JCA) revealed that a significant number of patients produce antibodies directed to individual histories and histone peptides. Fifty JCA patients, 58 healthy children and 58 children with autoimmune and rheumatologic disorders were studied for a presence of IgG- and IgM-antibodies against histone 1, histone 2 and histone 3 measured by ELISA. The levels of IgGand IgM-antibodies directed to histone 1, 2 and 3 were elevated in JCA as compared to the healthy controls. IgG-antibodies to histone 2 and IgM-antibodies to histone 3 also were elevated in comparison with the disease controls. IgG- and IgM-antibodies against histone 1 were found to be positive in 30 % and 26 % of JCA patients, respectively, in significant association with ANA (p = 0,038 and p = 0,03, respectively) and uveitis (p = 0,02 and p = 0,016, respectively). The same prevalence of IgG- and IgM-antibodies to histone 2 was established but only the IgG-isotype showed significant association with uveitis (p = 0,018). Anti-histone 3 IgG- and IgM-antibodies were found in 34 % and 27 % of JCA patients, respectively. IgM-antibodies to histone 3 were proved to be significantly associated with uveitis (p - 0,009). It was concluded that antibodies to histone 1, histone 2, and histone 3 represented a common serological feature of JCA. Their presence was related to the manifestation of chronic anterior uveitis, associated with JCA.


Keywords

Histones; antinuclear antibodies; chronic juvenile arthritis; uveitis; ELISA

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DOI: http://dx.doi.org/10.14748/ssm.v30i0.2858

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About The Authors

B. Varbanova

M. Baleva

K. Nikolov

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