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Scripta Scientifica Medica

HISTOLOGICAL AND ULTRASTRUCTURAL CHANGES IN THERMAL SKIN WOUNDS TREATED BY GENTAMID

E. Softova, N. Temnyalov, D. Zhelyazkov, M. Gardevski, N. Valova, G. Rashkova

Abstract

The healing of thermal skin wounds was investigated under experimental conditions on 96 male Wistar rats comparing the effect of Gentamycin ointment with that of the combination of Gentamycin and urea (i.e., with Gentamid, an ointment suggested by Zhelyazkov et al., 1984). The healing process was dynamically followed-up on the 3rd, 7th, 14th, and 21st day after burn. It was established that Gentamid treatment accelerated significantly more the regeneration process than that with 0,1 % ofGentamycin ointment alone. This was manifested by reduced tissue oedema and polymorphonuclear leukocyte infiltration and by stimulated granulation tissue formation as well leading to faster wound healing in Gentamid-treated animals.


Keywords

Thermic injury; Gentamid; Gentamycin; urea; wound healing; ultrastructure; rats

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DOI: http://dx.doi.org/10.14748/ssm.v28i0.3578

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About The Authors

E. Softova

N. Temnyalov

D. Zhelyazkov

M. Gardevski

N. Valova

G. Rashkova

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