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Scripta Scientifica Medica

N-terminal B-type natriuretic peptide (NT-probnp) in patients with obstructive sleep apnea syndrome

Diana Petkova, Yoto Yotov, Dobrin Paskalev, Yana Bocheva, Silva Andonova, Natalia Usheva

Abstract

The aim of the present study is to evaluate the plasma N-terminal pro BNP in patients with obstructive sleep apnea syndrome (OSAS). A prospective study of 40 patients was carried out. Thirteen of them were accepted for diagnostic evaluation of a suspected sleep apnea which was proved with polysomnography (PSG), 26 were with documented congestive heart failure (CHF). The values of NTpro-BNP are not different between the patients with OSAS without concomitant diseases. There is a significant difference in the NT pro-BNP in OSAS patients with and without arterial hypertension, as well as in patients with CHF. There is no association between the values of the natriuretic peptide and the variables assessing the severity of OSAS. In conclusion: the undiagnosed OSAS is not related with severe impairment of the left ventricular function. The analysis of the NT-pro-BNP in pa tients with possible OSAS may be used as a fast, easily accessible, and reliable diagnostic marker as well as suit able improving the treatment and control of the concomitant cardio vascular morbidity and mortality.

Scripta Scientifica Medica 2011;V.43(1):7-10


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DOI: http://dx.doi.org/10.14748/ssm.v43i1.396

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About The Authors

Diana Petkova
Medical University of Varna
Bulgaria

Department of Pulmonary Disease

Yoto Yotov
Medical University of Varna
Bulgaria

Department of Cardiology

Dobrin Paskalev
Medical University of Varna
Bulgaria

Department of Nephrology

Yana Bocheva
Medical University of Varna
Bulgaria

Central Clinical Laboratory

Silva Andonova
Medical University of Varna
Bulgaria

Department of Neurology

Natalia Usheva
Medical University of Varna
Bulgaria

Dept. of Social Medicine

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