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Scripta Scientifica Medica

КЛИНИКО-ЛАБОРАТОРНИ ПРОУЧВАНИЯ НА ЛЕКАРСТВЕНАТА АЛЕРГИЯ

Й. Григоров, Ив. Попов

Abstract

Investigation of the drug allergy on 224 patients has been made for a period of 5 years. 190 of the patients were tested with the most probable medicine which causes cutireaction. With 108 of the patients the tests were positive (or with 56,84%). Epicutaneous reactions were used for laboratory diagnosis (from 150 tests total, 27 were positive or 18%), as well as difusion in culture medium after Ochterlony (415 tests from which 85 positive or 20,48%). The medicines which cause allergic reaction or cutirection are as follows: 1) salicilates — 20,54%; 2) antibiotics — 16,97%; 3) large-spectrum antibiotics — 12.50%; 4) chinolines — 11,60%; 5) pyrosolonics — 8,04%; 6) tranquillizers— 2,68%; 7) anilines — 1,79%; 8) novocainics — 7,13%; 9) sulphonamides — 4,47%; 10) opium preparations — 3,57%; 11) others— 10,71%.

The clinical forms through which the above cutireactions manifest themselves are as loilows: dermatitis — 50%, drug urticaria — 22,22%, fixed dermatitis — 9,26%, Erythema nodosum — 6,48%, Erythema exs. multiforme — 4,63%, eczema — 2,78%, spastic bronchitis — 2,78%, purpura — 1,85%.


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DOI: http://dx.doi.org/10.14748/ssm.v8i0.4900

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Й. Григоров

Ив. Попов

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