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Scripta Scientifica Medica

A role for oxidative stress in Exfoliation Syndrome

Dimitar Kovachev, G. Koliakos, Tosho Mitov, R. Kovachev, D. Mitova


Exfoliation syndrome (XFS) is the most common identifiable condition leading to the development of open angle glaucoma. During cataract surgery aqueous humour samples were obtained from 25 consecutive eyes of 25 patients with XFS and an equal number of controls. We investigated the concentration of Endothelin-1 (ET-1) in the aqueous humour with and without XFS. The activity of growth factor was referred to as a percentage of the effect of foetal calf serum. Ascorbic acid concentration, a major antioxidant in the eye, was assessed with a microplate assay method. The increased concentrations of ET-1 and growth factor, and the depression of ascorbic acid in the aqueous humour of XFS patients provide evidence suggesting the possible role of the oxidative stress in the pathogenesis of XFS.

Scripta Scientifica Medica 2007;39(1):11-14

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About The Authors

Dimitar Kovachev
Medical University of Varna

Department of Biology

G. Koliakos
Aristotle University of Thessaloniki

Medical School, Department of Biochemistry, Thessaloniki

Tosho Mitov
St. Petka Medical Eye Center of Varna

R. Kovachev
St. Petka Medical Eye Center of Varna

D. Mitova
St. Petka Medical Eye Center of Varna

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