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Scripta Scientifica Medica

Relationship between blood pressure, cerebral blood flow velocity and white matter lesions in patients with hypertensive encephalopathy

Silva Andonova, Dimitar Minchev

Abstract

Purpose: The aim of this study is to find the relationships between blood pressure, cerebral blood flow velocity and white matter lesions. The blood pressure lowering could slow the progression of disease.

Methods: By 23 elderly individuals (mean age -65.7 years) with hypertensive encephalopathy was measured a blood flow velocity (BFV) and cerebral vasomotor reactivity(CVR) in the middle cerebral artery using a 2 -MHz pulsed Transcranial Doppler. MRI was done at the beginning of the study and at 24 months to mea sure the severity of white matter hypertensities. The blood pressure was measuring frequently and on these bases the patients were divided into two groups: A-9 patients with high hypertension and B-14 patients with low or middle. All used an ACE-inhibitor alone or in combination with a diuretic.

Results: The differences in blood flow velocity and cerebral vas motored activity and MRI findings- hyper intensity periventricular and in deep white matter were significant among different severity of blood pressure. Group A - mean BFV-left 40 +/- 10 sm/s; right-42 +/- 10 sm/s;IR-0,65-0,68 Group B - mean BFV-left 54+/- 10 sm/s; right-56 +/- 10 sm/s, IR-0,60-0,64 (p<0,001)(fig 1).Elevated hyper tension correlated with grow of white matter hypertensities on MRI.

Conclusions: The findings in our study suggest that dysfunction of cerebral blood flow velocity might be an important factor in the development of white matter lesions in elderly with hyper tension. The treatment with antihypertensive agents lower risk of developing new white matter hypertensities and slowed the progression of hypertensive encephalopathy.

Scripta Scientifica Medica 2007; 39(1):39-40


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DOI: http://dx.doi.org/10.14748/ssm.v39i1.507

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About The Authors

Silva Andonova
Medical University of Varna
Bulgaria

Department of Neurology

Dimitar Minchev
Medical University of Varna
Bulgaria

Department of Neurology

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