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Scripta Scientifica Medica

ЦИТОХИМИЧНИ ПРОУЧВАНИЯ ПРИ НЯКОИ КРЪВНИ ЗАБОЛЯВАНИЯ В ДЕТСКАТА ВЪЗРАСТ

Ст. Димитров, E. Дянков

Abstract

The authors report the results of personally carried out cytochemical investigations (desoxyribonucleic acid (DNA), ribonucleic acid (RNA), glycogen, lipids, oxidase and peroxidase) on the cells of peripheral blood in 37 children, affected with blood disease (leukoses, lymphogranulomatosis, panmyelopathy, megaloblastic (familial) anemia, chronic hemolytic anemia, thalassemia (Mediterranean anemia) and iron deficiency anemia).

In cases with acute leukosis, with fully developed clinical picture or recurrence, a reduction of DNA is established. The RNA is insignificantly increased. The glycogen in acute leukosis is reduced and during remissions - elevated. A fall of the lipid level is furthermore noted. (In the case with chloroleukosis, the ribonucleic acid is reduced).

In malignant lymphogranulomatosis, the DNA is found in moderate quantities. In children with panmyelopathia, the DNA in the segmento- nucleated leukocytes and lymphocytes is decreased. The desoxyribonucleic acid in megaloblastic anemia cases displayed a moderate quantity.

The content of DNA, RNA, glycogen, lipids, oxidase and peroxidase in chronic hemolytic anemia, thalassemia and iron deficiency anemia fluctuates within the limits of moderate and large quantities.


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DOI: http://dx.doi.org/10.14748/ssm.v7i0.5120

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Ст. Димитров

E. Дянков

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