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Mortality in childhood-onset type 1 diabetes

Elitsa Hadzhieva, Mila Boyadzhieva, Violeta Iotova, Sonya Galcheva, Kaloyan Tsochev, Tatiana Chalykova, Yoto Yotov, Boyan Balev, Yana Bocheva, Nataliya Usheva, Ruzha Pancheva

Abstract

It is well-recognized that diabetes-related complications are the leading cause of the still increased morbidity and mortality from diabetes and exert a heavy economic burden on society. The discovery of insulin led to a dramatic change in life expectancy of patients with type 1 diabetes (T1D). Furthermore, it caused a major shift in the distribution of causes of death - from diabetic coma in the pre-insulin era, to long-term complications being the predominant causes of death nowadays. The aim of the present review is to assess the trends in the absolute and the relative mortality rates as well as the leading causes of death among patients with childhood-onset (< 18 years) T1D in populations from different latitudes. It is also observed how disease duration, age at diagnosis, and year of diagnosis affect these mortality trends. Eight population-based studies published in English in the last 14 years, as well as another one, published in 2001, with different duration of follow-up, are included in the review. However, it is hard to compare different populations due to the dissimilarities in the study methods and the characteristics of the examined cohorts.

Keywords

childhood-onset type 1 diabetes; trends in mortality; causes of death

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DOI: http://dx.doi.org/10.14748/ssm.v51i1.5913

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About The Authors

Elitsa Hadzhieva
Clinic of Endocrinology and Metabolic disease, Faculty of Medicine; Medical University of Varna
Bulgaria

Mila Boyadzhieva
Clinic of Endocrinology and Metabolic disease, Faculty of Medicine; Medical University of Varna

Violeta Iotova
Department of Paediatrics, Faculty of Medicine; Medical University of Varna

Sonya Galcheva
Department of Paediatrics, Faculty of Medicine; Medical University of Varna

Kaloyan Tsochev
Department of Paediatrics, Faculty of Medicine; Medical University of Varna

Tatiana Chalykova
First Clinic of Cardiology, Faculty of Medicine; Medical University of Varna

Yoto Yotov
First Clinic of Cardiology, Faculty of Medicine; Medical University of Varna

Boyan Balev
Department of Diagnostics Imaging and Radiotherapy; Medical University of Varna

Yana Bocheva
Department of General Medicine and Clinical Laboratory, Faculty of Medicine; Medical University of Varna

Nataliya Usheva
Department of Social Medicine and Health Care Organisation, Faculty of Public Health; Medical University of Varna

Ruzha Pancheva
Department of Hygiene and Epidemiology, Faculty of Public Health; Medical University of Varna

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