Scientific Online Resource System

Scripta Scientifica Medica

Changes in the sera levels of amyloid A protein in the course of influenza, chickenpox and infectious mononucleosis

Iliyan Todorov, Yana Bocheva, Margarita Gospodinova, Gergana Popcheva, Yordan Yordanov

Abstract

Introduction: Until now, there has been no routinely measured laboratory marker, which indicates acute inflammation from viral origin. According to some authors, the serum amyloid A (SAA) protein is of great importance in such circumstances.

Aim: The aim of this article is to establish the clinical significance of SAA as a potential laboratory marker for viral infections.

Materials and Methods: Sera samples from 93 subjects with different viral infections, including influenza (n=31), infectious mononucleosis (n=31), and chickenpox (n=31) were analyzed. Levels of SAA were prospectively measured by immunoturbidimetry, adapted on Olympus AU 400. Thirty healthy subjects were included in the control group.

Results: In comparison with the control group, the levels of SAA were significantly higher, reaching a mean concentration of up to 180.80±199.87 mg/L. During convalescence, the levels decreased dramatically achieving a level of up to 31.29±83.42 mg/L. The highest concentrations were registered in the cases with different complications, such as secondary bacterial infections. In comparison with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and leukocytes, SAA levels were statistically significant for minor inflammatory stimuli, such as viral infections are.

Conclusion: SAA increases significantly in the course of different viral infections, such as influenza, infectious mononucleosis, and chickenpox. Early normalization of its levels correlates with full recovery, lack of complications and auspicious prognosis of the disease.


Keywords

serum amyloid A, virus, inflammation, acute phase response, immune

Full Text


References

Genev G, Popova M. Klinichna stoinost na savremennite izsledvaniya v infektologiyata. Plovdiv, Bulgaria: Meditsinsko izdatelstvo Raikov; 2006. (in Bulgarian).

Peter J. Use and interpretation of laboratory tests in infectious diseases. 6th Edition. Specialty Laboratories; 2000.

Lannergard A, Larsson A, Kragsbjerg P, Friman G. Correlations between serum amyloid A protein and C-reactive protein in infectious diseases. Scand J Clin Lab Invest. 2003; 63(4):267 – 72.

Shainkin-Kestenbaum R, Zimlichman S, WinikoffY, Pras M. Chaimovits C, Sarov I. Serum amyloid A (SAA) in viral infection: rubella, measles and subacute sclerosing panencephalitis (SSPE). Clin Exp Immunol. 1982;50(3):503-6.

Miwata H, Yamada T, Okada M, Kudo T, Kimura H, Morishima T. Serum amyloid A protein in acute viral infections. Arch Dis Child. 1993;68(2):210–4.

Tian Y, Li W, Ye Z. Determinations of serum amyloid A and C-reactive protein for the diagnosis of infectious diseases in children[J]. Laboratory Med. 2017;32(5):382-5.

Nakayama T, Sonoda S, Urano T, Yamada T, Okada M, Monitoring both serum amyloid A protein and C-reactive protein as inflammatory markers in infectious diseases. Clin Chem. 1993;39(2):293-7.

Niemi K. Serum amyloid A (SAA): proinflammatory functions and their regulation by serum lipoproteins. Academic dissertation. Helsinki;2012.

Salini V, Saggini A, Maccauro G, Caraffa A, Shaik-Dasthagirisaheb YB, Conti P. Inflammatory markers: serum amyloid A, fibrinogen and C-reactive protein – a revisited study. Eur J Inflamm. 2011;9(2):95-102.

Falsey A, Walsh E, Francis C, Looney R, Kolassa J, Hall W, et al. Response of C-reactive protein and serum amyloid a to influenza a infection in older adults. J Infect Dis. 2001;183(7):995-9.

Yamada T. Inflammatory markers; C-reactive protein (CRP) and serum amyloid A (SAA). Rinsho Byori. 2005;53(6):558-61.




DOI: http://dx.doi.org/10.14748/ssm.v51i1.6035

Refbacks

About The Authors

Iliyan Todorov
MU - Varna
Bulgaria

Yana Bocheva
MU - Varna
Bulgaria

Margarita Gospodinova
MU - Varna
Bulgaria

Gergana Popcheva
MU - Varna
Bulgaria

Yordan Yordanov
St. Nikolay Chudotvoretz, Eye Clinic Varna
Bulgaria

Font Size


|