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Varna Medical Forum

Adiponectin, some markers of metabolic risk and abdominal obesity in preschool age

Mina Lateva, Violeta Iotova, Ralitsa Popova, Sonya Galcheva, Miglena Georgieva, Trifon Chervenkov, Yana Bocheva


All the studies in the Balkan countries, over the last decade, found an increasing incidence of obesity. Abdominal obesity is considered with higher morbidity,due to the higher metabolic activity of the abdominal fat mass, which is characterized by low-level chronic inflammation.

OBJECTIVE: to establish a link between (abdominal) fat mass and some metabolic markers in preschool age.

PARTICIPANTS AND METHODS: height, weight and waist circumference (WC) of 40 healthy children living in Varna district were measured, mean age 5.31 years (4-7 yr.). Normal weight, overweight and (abdominal) obesity was defined by BMI and CDC reference values according to sex and age. Biochemical tests were taken after 12 hours of overnight fasting. Children wore pedometers to measure physical activity. In order to determine and validate the abdominal obesity a DXA study was performed.

RESULTS: With obesity were 17.5% of respondents, and only 9.7% of all meet the minimum recommendations for physical activity during the week and 16.1% at weekends. Fat mass correlated significantly with BMI and WC (p <0.001), and of metabolic markers it correlated with hsCRP (r=0,533, p=0,04), as well as with elevated cholesterol levels (r=0,458, р=0,016). A significant correlation between serum leptin and BMI, WC, fat mass (p<0.001), as well as total cholesterol (r=0,482, р=0,008) and lower levels of LDL-cholesterol (r=0,434, р=0,019) was found. Levels of serum adiponectin correlated inversely with weight (r=-0,415, p=0,025), when controlling for the level of physical activity with WC too (r=-0,437, p=0,042).

CONCLUSION: This study found a significant association between waist circumference, fat mass and established metabolic risk markers in healthy children even at this early age.


metabolic risk; adiponectin; abdominal obesity; preschoolers

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