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Varna Medical Forum

InteRhemispheric differences in clinical outcome after intravenous thrombolysis

Darina Georgieva-Hristova, Silva Andonova, Evgeniya Kalevska, Cvetomila Dimitrova


The human brain is characterized by functional asymmetry including interhemispheric, cortical and subcortical interactions. Patients with acute ischemic stroke (AIS) in the left hemisphere and conducted thrombolytic therapy (IVT) have a two-fold greater likelihood of favorable clinical outcome of the third month compared with right hemispheric infarcts. Petticoats and left - sided location are predictors of significant improvement in neurological deficit 24 hours after IVT. On the other hand the association of male and right - sided location of stroke is associated with a greater likelihood of favorable clinical outcomes than women with the same location. In men it is associated with a better outcome than left-sided localization of the lesion.


Thrombolisis, stroke, age,outcome;

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