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Stroke - disturbance of intestinal mucosal barrier function

Darina Georgieva-Hristova


The incidence of sudden death after stroke varies from 2% to 6%, and two leading non-neurological causes are heart function disorders and infections. Acute brain injury induces various autonomic, neuro-endocrine and inflammatory changes which are manifested in certain organs in the body, leading to immunosuppression and development of inflammatory complications.
The intestinal microbiota plays a key role in the maintenance of homeostasis, such as distortions in its regulation may result in severe inflammatory diseases. Immune depression following stroke, affects the intestinal mucosa and lead to distortion of its barrier function, which can lead to increased bacterial translocation, septicemia and systemic infections. It is believed to be a cytokine-mediated anti-inflammatory response to pathogenic factor in the development of infections after stroke. Peptococcaceae levels in stroke, increasing more than three times. These changes in colonic microflora associated with increased levels of norepinephrine and noradrenergic innervation.


stroke, gut, inflammation, microbiota.

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