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Varna Medical Forum

COCKROFT GAULT FORMULA AND RENAL FUNCTION ASSESSMENT IN HEALTHY ELDERLY SUBJECTS AGED OVER 80 YEARS

V. Todorova, S. Madjova, S. Nedev

Abstract


It is known that renal function decreases with ageing. At the same time, the level of serum creatinine may remain normal. Its formation correlates with muscle mass, which is reduced in the elderly. Usage of the Cockcroft Gault formula to calculate the glomerular filtration rate may reveal initial renal failure and help dosing of many drugs administered in elderly. We studied two groups of elderly persons (without any evidence of kidney disease, hypertension and diabetes mellitus: group A (80-90 years); Group B (over 90 years) as well as a control group C (30-40 years). Serum creatinine was estimated by the method of Jaffe and glomerular filtration rate was calculated by Cockroft Gault formula. The mean serum creatinine levels were of 109,83±15,10 ìmol/L in group A, 101,94±33,18 ìmol/L in group B and 95,00±18,40 ìmol/L in group C. The mean values of glomerular filtration rate using this formula was of 30,14±5,17 mL/min in group A, 33,43±6,66 mL/min in group B and 84,93±18,1617 mL/min in the control group. In all the three groups normal serum creatinine was found, while glomerular filtration rate was significantly lower in both groups of elderly. In adult patients, drug therapy should correspond to the degree of renal function reduction.



Keywords

Cockroft Gault formula, creatinine, glomerular filtration rate, elderly


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