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Effect on pain and facial edema of platelet-rich plasma after extraction of retained teeth

Stelian Edrev, Stefan Peev


The effect on pain scores of platelet-rich plasma (PRP) applied alone or in combination either with collagen or with autologous bone was followed up on the first, third and seventh day after extraction of retained teeth in 66 patients, 29 males and 37 females, as well as in 24 patients without this treatment. The degree of postoperative facial edema was examined on the first day, too. An increased frequency of slightly expressed pain (with a summary score of 1 and 2 according to the visual analogue scale) was established after the treatment of post-extraction wounds of the retained teeth during the initial seven days by means of PRP alone as well as by means of both PRP and collagen, and both PRP and autologous bone, respectively. The mean pain scores between the first and seventh day after treatment were statistically significantly lower with the use of PRP alone (t=9.665; р<0.00001), PRP with collagen (t=10.175; р<0.00001) and PRP with autologous bone (t=12.516; р<0.00001). There was no statistical significance in terms of the mean differences between the effect on the degree of postoperative edema of these three methods of treatment of the retained teeth one towards another and towards the control patients. The application of PRP alone or in combination with collagen or autologous bone exerted a favorable influence on pain and facial edema in the patients with extracted retained teeth.


platelet-rich plasma, collagen, autologous bone, retained teeth, pain, facial edema

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