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Varna Medical Forum

Microribonucleic acids in children with Crohn’s disease

Krasimira Koleva, Miglena Georgieva

Abstract

In recent years, several microribonucleic acids (microRNA) have been used as promising non-invasive biomarkers in patients with ulcerative colitis. Quantitative characteristics of the expression of 11 different serum microRNAs were examined by means of real-time polymerase chain reaction in a total of 33 children. There were 22 children, 16 girls and six boys, aged between nine and 17 years with Crohn’s disease and 20 healthy children, 12 girls and eight boys, aged between four and 17 years. There was a higher expression of all the microRNAs in patients than in healthy children. The values of microRNA142-3p and microRNA642-b3 were statistically reliably greater in children with Crohn’s disease than in healthy children (t=2.05; p<0.05 and t=2.00; p<0.05, respectively). Some microRNAs play a diagnostic role in children with Crohn’s disease. An additional systematic research is needed for children and adults with this disease.

Keywords

Crohn’s disease, microribonucleic acids, children

Full Text


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