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Pain in osteoporosis - causes and pathogenesis

Vasilena Kuzmanova, Atanas Kuzmanov, Simeon Todorov, Stanislav Marchev, Stefka Valcheva-Kuzmanova


Osteoporosis is a pathological condition of bones caused mainly by accelerated osteoclast activity due to postmenopausal estrogen deficiency. Osteoporosis causes two types of pain: traumatic pain due to a fragility fracture and pain due to osteoporotic pathology without evidence of fracture. This review summarizes the available literature data on osteoporosis-related pain, with particular emphasis on the pathogenesis of pain resulting from osteoporotic pathology without evidence of fracture.


osteoporosis, pain, pathogenesis, review

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