In an elegant manner Viviana Triaca presented in this volume of Adipobiology her Homage to Rita Levi-Montalcini highlighting the significance of nerve growth factor (NGF) in the molecular mechanisms of Alzheimer's disease (AD). This remarkable review generates a completely new direction in understanding some of the new and specific aspect of AD pathology, focusing on the NGF modulation of amyloid precursor protein (APP) processing and metabolism. Dr Triaca provides a paradigm shift from "classical" cholinergic to NGF-centered approach showing that the dysregulation of NGF-TrkA (receptor tyrosine kinase A) and proNGF-p75NTR signaling systems is a good candidate for being primus movens in the pathogenesis of AD.
Adipobiology 2013; 5: 19-22.
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