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Adipobiology

The Adipose Mast Cell: Mastokines As Binary Modulators Of Disease Processes

Neşe Tunçel, Gorana Ranćić, Rouzha Z. Pancheva, Nikolai T. Evtimov

Abstract

A paradigm-shifting discovery of the hormone leptin (in the end of 1994) paved the way toward intensive studies on endocrine and paracrine function of the adipose tissue. Onwards, a wide range of signaling proteins collectively termed adipokines were identified as secretory products of adipose cells including mast cells, a “classical” companion of this tissue. The present review addresses the potential translational relevance of adipose paracrine signaling pertinent to various diseases, particularly atherosclerosis, metabolic syndrome, thyroid-associated (Graves’) ophthalmopathy, and breast and prostate cancer, with special reference to binary (protective versus pathogenic) roles of mastokines, mast cell-derived signaling proteins.

Keywords

adipose tissue, mast cells, mastokines, adipokines, pathogenesis, inflammation, diseases

Full Text


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DOI: http://dx.doi.org/10.14748/adipo.v11.8560

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About The Authors

Neşe Tunçel
Department of Physiology, Medical Faculty, Osmangazi University, Eskişehir, Turkey
Bulgaria

Gorana Ranćić
Department of Histology and Embryology, Medical Faculty, University of Niš, Niš, Serbia
Serbia

Rouzha Z. Pancheva
Department of Hygiene and Epidemiology, Medical University, Varna, Bulgaria
Bulgaria

Nikolai T. Evtimov
Department of Urology, University Hospital St. Anna, Medical University, Varna, Bulgaria
Bulgaria

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