Urinary tract infections are one of the most common nosocomial infections. The most common cause of urinary tract infections worldwide is Escherichia coli – a Gram (-) bacterium that normally inhabits the human gastrointestinal tract. When the bacterium enters other organs and cavities, it can cause inflammation. Possible clinical cases of infection with E. coli range from asymptomatic bacteriuria, which does not always require special treatment, to acute pyelonephritis or exacerbated chronic pyelonephritis. Treatment is complex, with the choice of antibiotic playing a major role. The aim of the article is to show the positive effect of antibiotic treatment, mainly fluoroquinolones, in patients with urinary tract infections and clinical cases related to the diagnosis of pyelonephritis, treated at the Clinic of Internal Medicine in the Military Medical Academy in Sofia.
Feather А, Randall, D, Waterhouse M. Clinical Medicine Kumar and Clark’s tenth edition. Elsevier, London, 2021. - xix, 1544 p. https://library.usmf.md/ro/intrari-noi-292021.
Херолд Г, и сътр. Вътрешни болести, част II- пето основно преработено и актуализирано българско издание под редакцията на доц. д-р Михаил Боянов,дмн, Издат.: Мед. Изд. „Шаров“, 2011,
Николов Ф, и сътр. Вътрешни болести, първо издание. Издателство “Лаксбук”, Пловдив, 2020; ISBN 978-619-. 189-145-0
Сурчева С, и сътр. Фармакология, учебник за студенти по дентална медицина. Изд.: Мед. изд. Арсо, София, 2020, ISBN - 978-619-197-047-6
Митов И, и сътр. Ръководство за практически упражнения по медицинска микробиология (част 2). Изд.: Мед. изд. Арсо, София, 2018, ISBN - 978-619-197-019-3
Гачев Е. Клинична фармакология и терапия. Изд.: Мед. изд. Арсо, София, 2018, ISBN - 978-619-197-031-5
Мутафчийски В, и сътр. Справочник за емпирична терапия на най-честите инфекции във ВМА и подчинените и структури. Изд.: Военномедицинска академия, София, 2019, ISBN - 978-619-7196-48-1
Вътрешен медицински архив на ВМА. (достъпен през м. септември 2025г.)
Bonkat G, et al. EAU Guidelines on Urological Infections. European Association of Urology, 2025.
Lelorier J, et al. Ciprofloxacin is more successful and cost-effective than trimethoprim/sulfamethoxazole in the oral ambulatory treatment of women with uncomplicated acute pyelonephritis. Value in Health. 1999;2(1):12. DOI: 10.1016/S1098- 3015(11)70070-5
Talan DA, et al. Comparison of ciprofloxacin (7 days) and trimethoprim-sulfamethoxazole (14 days) for acute uncomplicated pyelonephritis in women: a randomized trial. JAMA. 2000;283(12):1583. DOI: 10.1001/jama.283.12.1583
Barnawi MH, et al. Clinical and cost-effectiveness analysis of carbapenems versus ciprofloxacin in the treatment of urinary tract infections due to extended spectrum β-lactamase-producing Enterobacterales. European Journal of Clinical Pharmacology. 2023;79:399. DOI: 10.1007/s00228-022-03392-0
Rusu A, et al. Overview of side-effects of antibacterial fluoroquinolones: new drugs versus old drugs, a step forward in the safety profile? Pharmaceutics. 2023;15(3):804. DOI: 10.3390/pharmaceutics15030804
Гетова В, Момеков Г, Гетов И. Флуорохинолони – обобщен преглед на проблеми на безопасността и свързаните с тях ограничения. Обща медицина, 2021;23(1):27.
Belcheva V, Grigorov E, Balkanski S. Rational use of antibiotics and the importance of pharmacists’ support. Scripta Scientifica Pharmaceutica. 2022;9(1):21. DOI: 10.14748/ssp.v9i1.8593
Email this article (Login required) 
