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Annual for Hospital Pharmacy

Inhibitors of sodium-glucose linked transporter 2 - A new class antidiabetic drugs used for the treatment of diabetes mellitus type 2

Desimira Mironova, Evgeni Grigorov, Valentina Belcheva, Teodora Handjieva-Darlenska


Diabetes mellitus is a chronic disease, declared by the World Health Organization (WHO) as a pandemia, whose growth is progressing daily and affects both economically advanced and developing countries. This fact leads to a number of health, social and economic consequences that need to be surmount, both through measures to prevent and to clarify the pathophysiological mechanisms of the disease and the discovery of new therapeutic approaches for treating hyperglycemia and a decrease in the complications of the underlying disease. With the discovery of selective inhibitors of competitive Sodium-glucose co-transporter-2-inhibitors (abbreviated called SGLT2- inhibitors) begins a new era in the pharmacotherapy of diabetes mellitus type II. In this review are tracked mechanism of action and effects of drugs of that group.


Diabetes mellitus; obesity; treatment

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