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Annual for Hospital Pharmacy

Perspectives For Target Therapy In The Treatment Of Malignant Neoplasms Of The Urinary Bladder

Olga Antonova, Boris Mladenov, Simeon Rangelov, Chavdar Slavov, Draga Toncheva


The etiology, pathogenesis and treatment of malignant neoplasms of the bladder still address a number of issues. Several biomarkers have been identified showing differences in the molecular image of invasive and non-invasive uroepithelial carcinoma. These biomarkers are part of the factors responsible for the large variation in treatment even in tumors with the same histological diagnosis. Currently, standard systemic therapy includes various cytotoxic chemotherapy regimens and is based mainly on histological evaluation and tumor progression. Since May 2016, target therapy has been approved for the first time in the treatment of oncological bladder disease. Target therapy is used to stop the growth and spread of cancer cells by suppressing activated signaling pathways - most often fibroblast, epidermal and endothelial growth factor pathways. The choice of „ the right` drug is largely based on the molecular genetic diagnosis of the tumor and the presence of specific biomarkers indicating the applicability of one or another drug.
Significant progress has been made in the era of molecular diagnosis and target therapy, which leads to prolonged survival and improved quality of life of oncology patients. In this article, we examine the potential and existing options for the use of precision therapy in patients with uroeptithelial tumors.


uroepithelial tumors, target therapy, precision medicine

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