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Annual for Hospital Pharmacy

Current pharmacotherapy of uterine leiomyomas

Vesela Karamisheva


Uterine leiomyomas are the most common benign tumors in women. The main symptoms include abnormal uterine bleeding, dysmenorrhea, pelvic pain and infertility. Between 25 and 50% of patients with leiomyomas undergo surgical treatment - hysterectomy or myomectomy. In recent years, more ways for pharmacologic treatment of these tumors are being sought. The classic drugs to control fibroids are progestins and combined estrogen-progestin drugs. Significant advances in the treatment of uterine leiomyomas have been the use of gonadotropin-releasing hormone agonists and antagonists, as well as selective progesterone receptor modulators. There are many studies proving their effectiveness. This review brings together information on all therapies currently used to control the disease.


pharmacotherapy, uterine leiomyomas

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