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The Role Of Omega-3 Supplements On The Symptoms Of Autism In Children: A Narrative Review

Viktor Štrumbelj, Cameelia Leboeuf, Nour Elwakeel, Ruzha Pancheva

Abstract

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental conditions for which the direct cause is yet to be determined. ASD is characterised by impaired social interaction and social communication, speech and language disorders, rigid or repetitive behaviour with atypical or excessive interests for individual’s age and sociocultural context. There are many proposed treatments for autism and among them is omega-3 fatty acids (OFA), but their efficacy is yet to be proven. Considering the link between OFA and the function and development of the brain, it is reasonable to explore if supplementation could provide improvement of symptoms. The aim of this study is to review the possible role and effect of OFA supplementation on ASD symptoms. We conducted a narrative review, initially examining 145 articles from PubMed and Google Scholar. Out of these, 13 articles were selected for detailed review, without any time restriction. The keywords used were “omega-3,” “autism,” “children,” and “nutrition.” We selected articles that included OFA supplementation, children diagnosed with autism, and the impacts on autism symptoms. Our research has shown that omega-3 fatty acids supplementation could be beneficial in improving the core symptoms in children diagnosed with ASD. However, the data is still non-conclusive and further research is needed to confidently conclude whether OFA supplementation has a place in treatment of ASD.

Keywords

autism spectrum disorders, omega-3 fatty acids, children, nutrition

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References

Ann Katrin Sauer MSC, Janelle Stanton MSC, Sakshi Hans MSC, Andreas Grabrucker PHD. Autism Spectrum Disorders: Etiology and Pathology. Exon Publ 2021;1-15. doi: https://doi.org/10.36255/exonpublications.autism-spectrumdisorders.2021.etiology

Lai MC, Lombardo MV, Baron-Cohen S. Autism. Lancet 2014;383(9920):896-910. doi: https://doi.org/10.1016/S0140-6736(13)61539-1

ICD-11 for Mortality and Morbidity Statistics [Internet]. [cited 2024 Jul 19]. Available from: https://icd.who.int/browse/2024-01/mms/en#437815624. ICD reference: https://icd.who.int/browse/2024-01/mms/en#437815624

Zeidan J, Fombonne E, Scorah J, Ibrahim A, Durkin MS, Saxena S, et al. Global prevalence of autism: A systematic review update. J Int Soc Autism Res. 2022;15(5):778-90. doi: https://doi.org/10.1002/aur.2696

Genovese A, Butler MG. The Autism Spectrum: Behavioral, Psychiatric and Genetic Associations. Genes. 2023;14(3):677. doi: https://doi.org/10.3390/genes14030677

Mankad D, Dupuis A, Smile S, Roberts W, Brian J, Lui T, et al. A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism. Mol Autism. 2015;6:18. doi: https://doi.org/10.1186/s13229-015-0010-7

Johnson CR, Handen BL, Zimmer M, Sacco K. Polyunsaturated Fatty Acid Supplementation in Young Children with Autism. J Dev Phys Disabil. 2010;22(1):1-10. doi: http://dx.doi.org/10.1007/s10882-009-9152-x

DeFilippis M. The Use of Complementary Alternative Medicine in Children and Adolescents with Autism Spectrum Disorder. Psychopharmacol Bull. 2018;48(1):40-63. PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5765434/

Baethge C, Goldbeck-Wood S, Mertens S. SANRA - a scale for the quality assessment of narrative review articles. Res Integr Peer Rev. 2019 Mar 26;4(1):5. doi: https://doi.org/10.1186/s41073-019-0064-8

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting system-atic reviews. Br Med J. 2021;372:71. doi: https://doi.org/10.1136/bmj.n71

Mazahery H, Conlon CA, Beck KL, Mugridge O, Kruger MC, Stonehouse W, et al. A randomised controlled trial of vitamin D and omega-3 long chain polyunsaturated fatty acids in the treatment of irritability and hyperactivity among children with autism spectrum disorder. J Steroid Biochem Mol Biol. 2019 Mar 1;187:9–16. doi: https://doi. org/10.1016/j.jsbmb.2018.10.017

Doaei S, Bourbour F, Teymoori Z, Jafari F, Kalantari N, Torki SA, et al. The effect of omega-3 fatty acids supplementation on social and behavioral disorders of children with autism: a randomized clinical trial. Pedi-atr Endocrinol Diabetes Metab. 2021;27(1):12–8. doi: https://doi.org/10.5114/pedm.2020.101806

Bent S, Bertoglio K, Ashwood P, Bostrom A, Hendren RL. A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder. J Autism Dev Disord. 2011;41(5):545–54. doi: https://doi.org/10.1007/s10803-010-1078-8

Keim SA, Gracious B, Boone KM, Klebanoff MA, Rogers LK, Rausch J, et al. ω-3 and ω-6 Fatty Acid Supplemen-tation May Reduce Autism Symptoms Based on Parent Report in Preterm Toddlers. J Nutr. 2018;148(2):227–35. doi: https://doi.org/10.1093/jn/nxx047

de la Torre-Aguilar MJ, Gomez-Fernandez A, Flores-Rojas K, Martin-Borreguero P, Mesa MD, Perez-Navero JL, et al. Docosahexaenoic and Eicosapentaenoic Inter-vention Modifies Plasma and Erythrocyte Omega-3 Fatty Acid Profiles But Not the Clinical Course of Children With Autism Spectrum Disorder: A Randomized Control Trial. Front Nutr [Internet]. 2022 Mar 29 [cited 2024 Jul 5];9. Available from: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.790250/full. doi: https://doi.org/10.3389/fnut.2022.790250

Mazahery H, Conlon CA, Beck KL, Mugridge O, Kruger MC, Stonehouse W, et al. A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Au-tism Spectrum Disorder in Children. J Autism Dev Dis-ord. 2019;49(5):1778–94. doi: https://doi.org/10.1007/s10803-018-3860-y

Parellada M, Llorente C, Calvo R, Gutierrez S, Lázaro L, Graell M, et al. Randomized trial of omega-3 for autism spectrum disorders: Effect on cell membrane composition and behavior. Eur Neuropsychopharmacol. 2017;27(12):1319–30. doi: https://doi.org/10.1016/j. euroneuro.2017.08.426

Amminger GP, Berger GE, Schäfer MR, Klier C, Friedrich MH, Feucht M. Omega-3 Fatty Acids Sup-plementation in Children with Autism: A Double-blind Randomized, Placebo-controlled Pilot Study. Biol Psy-chiatry. 2007;61(4):551–3. doi: https://doi.org/10.1016/j. biopsych.2006.05.007

Bent S, Hendren RL, Zandi T, Law K, Choi JE, Widjaja F, et al. Internet-Based, Randomized, Controlled Trial of Omega-3 Fatty Acids for Hyperactivity in Autism. J Am Acad Child Adolesc Psychiatry. 2014;53(6):658–66. doi: https://doi.org/10.1016/j.jaac.2014.01.018

Meiri G, Bichovsky Y, Belmaker RH. Omega 3 Fatty Acid Treatment in Autism. J Child Adolesc Psychophar-macol. 2009;19(4):449–51. doi: https://doi.org/10.1089/cap.2008.0123

Ooi YP, Weng SJ, Jang LY, Low L, Seah J, Teo S, et al. Omega-3 fatty acids in the management of autism spec-trum disorders: findings from an open-label pilot study in Singapore. Eur J Clin Nutr. 2015;69(8):969–71. doi: https://doi.org/10.1038/ejcn.2015.28

Agostoni C, Nobile M, Ciappolino V, Delvecchio G, Tesei A, Turolo S, et al. The Role of Omega-3 Fatty Acids in Developmental Psychopathology: A Systematic Review on Early Psychosis, Autism, and ADHD. Int J Mol Sci. 2017;18(12):2608. doi: https://doi.org/10.3390/ijms18122608

Nevins JEH, Donovan SM, Snetselaar L, Dewey KG, No-votny R, Stang J, et al. Omega-3 Fatty Acid Dietary Sup-plements Consumed During Pregnancy and Lactation and Child Neurodevelopment: A Systematic Review. J Nutr. 2021;151(11):3483–94. doi: https://doi.org/10.1093/jn/nxab238

Liu TH, Wu JY, Huang PY, Lai CC, Chang JPC, Lin CH, et al. Omega-3 Polyunsaturated Fatty Acids for Core Symptoms of Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis of Randomized Controlled Trials. J Clin Psychiatry. 2023;84(5):22r14772. doi: https://doi. org/10.4088/jcp.22r14772

Burdge GC, Calder PC. Conversion of alpha$-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev. 2005;45(5):581–97. doi: https://doi.org/10.1051/rnd:2005047

Burdge GC, Wootton SA. Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and do-cosahexaenoic acids in young women. Br J Nutr. 2002 Oct;88(4):411–20. doi: https://doi.org/10.1079/bjn2002689

Punia S, Sandhu KS, Siroha AK, Dhull SB. Omega 3- metabolism, absorption, bioavailability and health benefits–A review. PharmaNutrition. 2019;10:100162. doi: http://dx.doi.org/10.1016/j.phanu.2019.100162

Madra M, Ringel R, Margolis KG. Gastrointestinal Issues and Autism Spectrum Disorder. Psychiatr Clin North Am 2021;44(1):69–81. doi: https://doi.org/10.1016/j. chc.2020.02.005

Abdel-Wahab BA, Al-Qahtani JM, El-Safty SA. Omega-3 polyunsaturated fatty acids in large doses attenuate seizures, cognitive impairment, and hippocampal oxida-tive DNA damage in young kindled rats. Neurosci Lett 2015;584:173–7. doi: https://doi.org/10.1016/j.neu-let.2014.10.003

Baird G, Cass H, Slonims V. Diagnosis of autism. Br Med J 2003;327(7413):488–93. doi: https://doi.org/10.1136/bmj.327.7413.488




DOI: http://dx.doi.org/10.14748/bmr.v35.10339

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About The Authors

Viktor Štrumbelj
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Cameelia Leboeuf
Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada

Nour Elwakeel
Faculty of medicine, Mansoura University, Mansoura, Egypt

Ruzha Pancheva
Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria

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