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Biomedical Reviews

Apoptosis in neurodegenerative diseases: to be or not to be? Absence of proof is not proof of absence

Henry Timmers, Berry H. P. H. Kremer


Apoptosis (from Greek falling off) is a term coined by Kerr, Wyllie and Currie in 1972 to describe a form of cell death associated with peculiar morphological changes. They contrasted apoptosis with necrosis, in which large numbers of cells undergo destruction and elicit a regional inflammatory response. In contrast, in apoptosis individual cells die and are being removed quickly, without inflammation, making their demise often difficult to detect. The initial concept of apoptosis was exclusively related to a morphological phenomenon.

Biomedical Reviews 1995; 4: 103-108.

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About The Authors

Henry Timmers
Radboud University Nijmegen

Berry H. P. H. Kremer
Radboud University Nijmegen

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