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Biomedical Reviews

Interaction of heat shock protein (hsp90) with the cytoskeleton: potential implication in intracellular transport

Christos Stournaras, Andrew N. Margioris, Achille Gravanis


In this article we will summarize the details concerning the association of 90kD heat shock protein (hsp90) with cytoskeletal structures and we will discuss the potential involvement of these interactions in the translocation of steroid hormone receptors to the cell nucleus. In cultured mammalian cells hsp90 has been found to be colocalized with both microtubules and cytokeratin intermediate filaments, whereas no association with actin filaments and vimentin intermediate filaments has been established. The colocalization of hsp90 with microtubules and cytokeratin in intact cells rises the possibility that cytoskeletal structures could serve as "rails" for the direct movement of the steroid hormone receptor via association-dissociation with hsp90 molecules from the cytoplasmic site of synthesis to the nuclear site of action.

Biomedical Reviews 1994; 3: 27-37.

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About The Authors

Christos Stournaras
University of Crete

Andrew N. Margioris
University of Crete

Achille Gravanis
University of Crete

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