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Biomedical Reviews

Calpain: a new matrix proteinase?

Katsuji Shimizu


Calpain, originally considered to be an intracellular proteinase, was demonstrated to be present extracellularly in growth cartilage of Wistar rat and also in synovial fluids of osteoarthritic patients. Proteoglycan-degrading proteolytic activities of calpain were demonstrated in vitro and in osteoarthritic synovial fluid. These data plus some recent reports of other investigators suggest that calpain-calpastatin system may have an important role in the metabolism of the extracellular matrix, although the pathways of externalization of these intracellular proteinases remain unclarified.

Biomedical Reviews 1992; 1: 69-72.

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Katsuji Shimizu
Kyoto University

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