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Manipulating Cytochrome P450 Enzymes: New Perspectives for Cancer Treatment

Stanislav Yanev, Tsveta Stoyanova


Increasing drug efficiency and reducing drug overall toxicity are two of the main goals of today`s drug chemotherapy of cancer. In general this could be achieved by searching new ways for selective active drug accumulation in cancer cells by manipulating local drug metabolism or delivery. In this short review, on the basis of the main directions described by McFadyen et al. (Mol Cancer Ther 2004; 3(3): 363-371), new data is reported for localization and expression of cytochrome P450 enzymes in human tumors, development of cytochrome P450-based and gene-directed enzyme activated prodrugs, antisense-based P450 and immune-based therapy, cytochrome P450 polymorphism in development of anticancer drugs. New discoveries of molecular biology of cancer give us hope for more successful development of modern cancer chemotherapy. Biomed Rev 2017; 28: 120-124.

Keywords: cytochrome P450 isoforms, cancer cells, drug metabolism, drug delivery

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About The Authors

Stanislav Yanev
Bulgarian Academy of Sciences, Sofia

Department of Drug Toxicology, Institute of Neurobiology

Tsveta Stoyanova
Bulgarian Academy of Sciences, Sofia

Department of Drug Toxicology, Institute of Neurobiology

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