Scientific Online Resource System

Biomedical Reviews

State-of-the-artery: periadventitial adipose tissue (tunica adiposa)

George N. Chaldakov, Marco Fiore, Peter I. Ghenev, Neşe Tunçel, Gorana Rančić, Pepa Atanassova, Luigi Aloe


Traditional view considers that the arterial wall is composed of three concentric tissue coats (tunicae): intima, media, and adventitia. However, large- and medium-sized arteries, where usually atherosclerosis develops, are consistently surrounded by periadventitial adipose tissue (PAAT). Here we update growing information about PAAT, and  conceptualize it as the fourth coat of arterial wall, that is, tunica adiposa (in brief, adiposa, like intima, media, adventitia). Recent evidence has revealed that adipose tissue expresses not only metabolic, but also secretory (endo- and paracrine) phenotype, producing/releasing a large number of signaling proteins collectively termed adipokines. Through paracrine ("vasocrine") way, adiposa-derived mediators may contribute to various arterial functions such as contraction-relaxation, smooth muscle cell growth, inflammation, hemostasis, and innervation, hence to "outside-in" signaling pathway of atherogenesis.

Biomedical Reviews 2009; 20: 41-44.

Full Text



Article Tools
Email this article (Login required)
About The Authors

George N. Chaldakov
Medical University of Varna

Marco Fiore
National Research Council of Rome

Peter I. Ghenev
Medical University of Varna

Neşe Tunçel
Eskisehir Osmangazi University

Gorana Rančić
University of Niš

Pepa Atanassova
Medical University of Plovdiv

Luigi Aloe
National Research Council of Rome

Font Size