Although knowing much about the neuronal life and death, we remain unsure of their exact molecular nature. As often occurs, the framework of an initial concept of the physiological role of a newly discovered molecules extends in the light of emerging findings. This is also the case with the neurotrophin brain-derived neurotrophic factor (BDNF) and the neurotransmitter glutamate.
Biomedical Reviews 2008; 19: 29-32.