Adipose tissue's secretory phenotype paradigm shift has been upregulating since December 1, 1994, the birthday of leptin, an endocrine signaling protein (adipokine), which triggered the development of adipoendocrinology. Today, more than hundred adipokines are identified. Here an update of adipose-derived neurotrophic factors and neuropeptides and their receptors is presented, raising a hypothesis of neuroendocrine potential of this dynamic tissue.
Biomedical Reviews 2008; 19: 45-48.