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Biomedical Reviews

Galectin-3: multiple clinical applications

Antoniya Kisheva, Yoto Yotov


Galectin-3 is a β-galactoside binding lectin, containing carbohydrate-recognition domain, which interacts with a number of ligands. It is found in many tissues and is distributed intra– and extracellularly. The localization of the biomarker determines its function. Galectin-3 is involved in variety of biological processes sush as inflammation, fibrosis, immunological response and neoplastic growth. It may be used as a diagnostic or prognostic biomarker especially in cancer and cardiovascular diseases. The present review summarizes some of the properties of this biomarker.


Galectin-3, inflammation, fibrosis, cancer, cardiovascular diseases, microtubules

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About The Authors

Antoniya Kisheva
Medical University of Varna

First Department of Internal Diseases, ES Cardiology

Yoto Yotov
Medical University of Varna

First Department of Internal Diseases, ES Cardiology

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