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Petition for the recognition of Gheorghe Benga, as a discoverer of the first water channel protein in the human red blood cell membrane, several years before

Gheorghe Benga


In 1986, Benga and coworkers clearly demonstrated for the first time the presence and location of a water channel protein in the human red blood cell (RBC) membrane among polypeptides migrating in the region of 35-60 kD on the electrophoretogram of RBC membranes, labeled with [203]Hg-p-chloromercuribenzene sulfonate (PCMBS) under conditions for the specific inhibition of water diffusion. I suggested that a minor membrane component that binds PCMBS is involved in water transport and also indicated the way in which the specific protein could be further characterized: by purification and reconstitution in liposomes. In the same year the labeling experiments were confirmed and extended, and in the following 2-3 years I described the novelty of our work in several reviews.

Biomedical Reviews 2006; 17: ix-xi.

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About The Author

Gheorghe Benga
Iuliu Hațieganu University of Medicine and Pharmacy of Cluj-Napoca

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