Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, et al. Initial sequencing and analysis of the human genome. Nature 2001; 409: 860–921. DOI: 10.1038/35057062
Orgel LE, Crick FH. Selfish DNA: the ultimate parasite. Nature 1980; 284: 604–607. DOI:10.1038/284604a0
de Koning AP, Gu W, Castoe TA, Batzer MA, Pollock DD. Repetitive elements may comprise over two-thirds of the human genome. PLoS Genet 2011; 7, e1002384. DOI:10.1371/journal.pgen.1002384
Gall JG. Chromosome structure and the C-value paradox. J Cell Biol 1981; 91: 3–14. DOI:10.1083/jcb.91.3.3s
Waddington C H. The epigenotype. Endeavour 1942; 1: 18-20.
Wu C-t, Morris JR. Genes, genetics, and epigenetics: A correspondence. Science 2001; 293: 1103-1105. DOI:10.1126/science.293.5532.1103
Slotkin RK, Martienssen R. Transposable elements and the epigenetic regulation of the genome. Nat Rev Genet 2007; 8: 272–285. DOI:10.1038/nrg2072
Carey N. The Epigenetic Revolution. How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance. Columbia University Press, New York, 2012.
Feil R, Fraga MF. Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet 2012; 13: 97–109. DOI:10.1038/nrg3142
Baccarelli A, Bollati V. Epigenetics and environmental chemicals. Curr Opin Pediatr 2009; 21, 243–251. DOI:10.1097/mop.0b013e32832925cc
Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ. Developmental origins of noncommunicable disease: implications for research and public health. Environ Health 2012; 11: 42. DOI: 10.1186/1476-069X-11-42
Tobi EW, Lumey LH, Talens RP, Kremer D, Putter H, Stein AD, et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet 2009; 18, 21: 4046-4053. DOI: 10.1093/hmg/ddp353
Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, Susser ES, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci USA 2008; 105: 17046–17049. DOI: 10.1073/pnas.0806560105
Carito V, Parlapiano G, Rasio D, Paparella R, Paolucci V, Ferraguti G, et al. Fetal alcohol spectrum disorders in pediatrics FASD and the paediatrician. Biomed Rev 2018; 29: 27-35. DOI: 10.14748/bmr.v29.5847
Ciafrè S, Carito V, Tirassa P, Ferraguti G, Attilia ML, Ciolli P, et al. Ethanol consumption and innate neuroimmunity. Biomed Rev 2017; 28: 49-61. DOI: 10.14748/bmr.v28.4451
Ciafrè S, Carito V, Ferraguti G, Greco A, Chaldakov G, Fiore M, et al. How alcohol drinking affects our genes: an epigenetic point of view. Biochem Cell Biol 2018; 97, 4: 345-356. DOI: 10.1139/bcb-2018-0248
Ciafrè S, Ferraguti G, Greco A, Polimeni A, Ralli M, Ceci FM, et al. Alcohol as an early life stressor: Epigenetics, metabolic, neuroendocrine and neurobehavioral implications. Neurosci Biobehav Rev 2020; 118: 654-668. DOI: 10.1016/j.neubiorev.2020.08.018
Carito V, Ceccanti M, Ferraguti G, Coccurello R, Ciafrè S, Tirassa P, et al. NGF and BDNF alterations by prenatal alcohol exposure. Curr Neuropharmacol 2019; 17, 4: 308–317. DOI: 10.2174/1570159X15666170825101308
Ceccanti M, Coccurello R, Carito V, Ciafrè S, Ferraguti G, Giacovazzo G, et al. Paternal alcohol exposure in mice alters brain NGF and BDNF and increases ethanol-elicited preference in male offspring. Addict Biol 2016; 21, 4:776-787. DOI: 10.1111/adb.12255
Tippin B, Pham P, Goodman MF. Error-prone replication for better or worse. Trends Microbiol 2004; 12, 6: 288-295. DOI:10.1016/j.tim.2004.04.004
Gillespie MN, Wilson GL. Bending and breaking the code: dynamic changes in promoter integrity may underlie a new mechanism regulating gene expression. Am J Physiol Lung Cell Mol Physiol 2007; 292: L1-L3. DOI:10.1152/ajplung.00275.2006
Ollikainen M, Smith KR, Joo EJ, Ng HK, Andronikos R, Novakovic B, et al. DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome. Hum Mol Genet 2010; 19, 21, 4176-4188. DOI: 10.1093/hmg/ddq336
Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 2003; 23: 15: 5293-5300. DOI:10.1128/mcb.23.15.5293-5300.2003
Guy J, Gan J, Selfridge J, Cobb S, Bird A. Reversal of neurological effects in a mouse model of Rett syndrome. Sci-ence 2007; 315: 1143-1147 DOI:10.1126/science.1138389
Dias BG, Ressler KJ. Parental olfactory experience influences behavior and neural structure in subsequent generations. Nat Neurosci 2014; 17: 89-96. DOI: 10.1038/nn.3594
Dunn GA, Bale TL. Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology 2009; 150: 4999–5009. DOI: 10.1210/en.2009-0500
Crews D, Gillette R, Scarpino SV, Manikkam M, Savenkova MI, Skinner MK. Epigenetic transgenerational inheritance of altered stress responses. Proc Natl Acad Sci USA 2012; 109, 23: 9143–9148. DOI: 10.1073/pnas.1118514109
Painter R, Osmond C, Gluckman P, Hanson M, Phillips D, Roseboom T. Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG 2008; 115: 1243–1249. DOI: 10.1111/j.1471-0528.2008.01822.x
Veenendaal M, Painter R, de Rooij S, Bossuyt P, van der Post J, Gluckman P, et al. Transgenerational effects of prenatal exposure to the 1944–45 Dutch famine. BJOG 2013; 120: 548–554. DOI: 10.1111/1471-0528.12136
Moore R, Kaletsky R, Murphy C. Piwi/PRG-1 Argonaute and TGF-ẞ mediate transgenerational learned pathogenic avoidance. Cell 2019; 177: 1827–1841. DOI: 10.1016/j. cell.2019.05.024
McGowan PO, Sasaki A, D’Alessio AC, Dymov S, Labonté B, Szyf M, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009; 12: 3: 342-348. DOI: 10.1038/nn.2270
Oberlander TF, Weinberg J, Papsdorf M, Grunau R, Misri S, Devlin AM. Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics 2008; 2: 97-106. DOI:10.4161/epi.3.2.6034
Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmühl Y, Fischer D, et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 2009; 12: 1559-1566. DOI: 10.1038/nn.2436
Weaver I, Cervoni N, Champagne F, D’Alessio A, Sharma S, Seckl J, et al. Epigenetic programming by maternal behaviour. Nat Neurosci 2004; 7: 847-854 DOI:10.1038/nn1276
Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, et al. Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. Biol Psychiatry 2016; 80: 372–380. DOI: 10.1016/j.biopsych.2015.08.005
Vaage AB, Thomsen PH, Rousseau C, Wentzel-Larsen T, Ta TV, Hauff E. Paternal predictors of the mental health of children of Vietnamese refugees. Child Adolesc Psychiatry Ment Health 2011; 5: 2. DOI: 10.1186/1753-2000-5-2
Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983; 301: 89-92. DOI:10.1038/301089a0
Yokochi T, Robertson KD. Preferential methylation of unmethylated DNA by mammalian de novo DNA methyl-transferase Dnmt3a. J Biol Chem 2002; 277: 11735-11745. DOI:10.1074/jbc.M106590200
Esteller M, Fraga MF, Guo M, Garcia-Foncillas J, Hedenfalk I, Godwin AK. DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet 2001; 10: 3001-3007. DOI:10.1093/hmg/10.26.3001
Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 2000; 16: 168-174. DOI:10.1016/s0168-9525(99)01971-x
Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004; 429: 457-463. DOI:10.1038/nature02625
Nagarajan RP, Hogart AR, Gwye Y, Martin MR, LaSalle JM. Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation. Epigenetics 2006; 1: 4, e1–11. DOI:10.4161/epi.1.4.3514
Lu H, Liu X, Deng Y, Qing H. DNA methylation, a hand behind neurodegenerative diseases. Front Aging Neurosci 2013; 5: 1-16. DOI: 10.3389/fnagi.2013.00085
McCarrey JR. The epigenome as a target for heritable environmental disruptions of cellular function. Mol Cell Endocrinol 2012; 354, 1-2: 9-15. DOI: 10.1016/j. mce.2011.09.014
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