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COVID-19 as an oxygen-deprivation disease

Stanislav Yanev

Abstract

Since the last year, the epidemic with the new coronavirus SARS-CoV-2 has accumulated a wealth of data. The genetic structure of the virus, the epidemiological characteristics of the spread, the main clinical manifestations, the risks of the healing process, and the approaches for therapeutic intervention, etc. are the main areas into which the information can be parsed. The experimental and clinical data confirm the view that the new coronavirus causes pathogenic changes, which can be summarized as hypoxic syndrome. In this Dance Round, I shall succinctly justify this claim.

Keywords

SARS-CoV-2, hemoglobin, iron, hypoxia

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References

Liu W, Li H. COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Heme Metabolism. 2020; https://chemrxiv.org/ndownloader/files/22283226

Wen-zhong L, Hua-lan L, Liu W, Li H. COVID-19 Dis-ease: ORF8 and Surface Glycoprotein Inhibit Heme Metabolism by Binding to Porphyrin. 2020; DOI:10.26434/chemrxiv.11938173.v2

Abozeid Y, Ismail NSM, McLean GR, Hamdy NM. A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection. Eur J Pharm Sci 2020; 153: 105465. DOI: 10.1016/j. ejps.2020.105465

Algassim AA, Elghazaly AA, Alnahdi AS, Mohammed-Rahim OM, Alanazi AG, Aldhuwayhi NA, et al. Prognostic significance of hemoglobin level and autoimmune hemolytic anemia in SARS-CoV-2 infection.Ann Hema-tolDOI: 10.1007/s00277-020-04256-3

Lippi G, Mattiuzzi C. Hemoglobin value may be decreased in patients with severe coronavirus disease 2019. Hematol Transfus Cell Ther 2020; 42(2): 116-117. DOI: 10.1016/j. htct.2020.03.001

Lv Y, Chen L, Liang X, Liu X, Gao M, Wang Q, et al. Association between iron status and the risk of adverse outcomes in COVID-19. Clin Nutr 2020. DOI: 10.1016/j. clnu.2020.11.033

San Juan I, Bruzzone C, Bizkarguenaga M, Bernardo-Seisdedos G, Laín A, Gil-Redondo R, et al. Abnormal concentration of porphyrins in serum from COVID-19 patients. Br J Haematol 2020; 190(5): e265-e267. DOI: 10.1111/bjh.17060

Taneri PE, Gómez-Ochoa SA, Llanaj E, Raguindin PF, Rojas LZ, Roa-Díaz ZM, et al. Anemia and iron metabo-lism in COVID-19: a systematic review and meta-analysis. Eur J Epidemiol 2020; 35(8): 763-773. DOI: 10.1007/s10654-020-00678-5

Torti L, Maffei L, Sorrentino F, De Fabritiis P, Miceli R, Abruzzese E. Impact of SARS CoV-2 in Hemoglobinopathies with Immune Disfunction and Epidemiology. A Protective Mechanism from Beta Chain Hemoglobin Defects? Mediterr J Hematol Infect Dis 2020; 12(1): e2020052-e2020052. DOI: 10.4084/MJHID.2020.052

Karimi M, Haghpanah S, Azarkeivan A, Zahedi Z, Zarei T, Akhavan Tavakoli M, et al. Prevalence and mortality in β-thalassaemias due to outbreak of novel coronavirus disease (COVID-19): the nationwide Iranian experience. Br Haematol 2020; 190(3): e137-e140. DOI: 10.1111/bjh.16911

Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the re-cently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 2020; 30(3): 269-271. DOI: 10.1038/s41422-020-0282-0

Quiros Roldan E, Biasiotto G, Magro P, Zanella I. The possible mechanisms of action of 4-aminoquinolines (chloroquine/hydroxychloroquine) against SARS-CoV-2 infection (COVID-19): A role for iron homeostasis?Pharmacol Res 2020; 158: 104904. DOI: 10.1016/j. phrs.2020.104904

Perricone C, Bartoloni E, Bursi R, Cafaro G, Guidelli GM, Shoenfeld Y, et al. COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy. Immunol Res 2020; 68(4): 213-224. DOI: 10.1007/s12026-020-09145-5

Vlahakos VD, Marathias KP, Arkadopoulos N, Vlahakos DV. Hyperferritinemia in patients with COVID-19: An opportunity for iron chelation? Artif Organs 2020; DOI: 10.1111/aor.13812

Dalamaga M, Karampela I, Mantzoros CS. Commentary: Could iron chelators prove to be useful as an adjunct to COVID-19 Treatment Regimens? Metabolism 2020; 108: 154260. DOI: 10.1016/j.metabol.2020.154260

Liu W, Zhang S, Nekhai S, Liu S. Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival. Curr Clin Microbiol Rep 2020:1-7. DOI: 10.1007/s40588-020-00140-w

Abbas A, Mostafa A, Yousof E, Ss A. Use of Iron Chela-tors to Reduce the Severity of COVID-19. 2020; 4: 1042.

Abobaker A. Can iron chelation as an adjunct treatment of COVID-19 improve the clinical outcome? Eur J Clin Pharmacol 2020; 76(11): 1619-1620. DOI: 10.1007/s00228-020-02942-9

Loh D. The potential of melatonin in the prevention and attenuation of oxidative hemolysis and myocardial injury from CD147 SARS-CoV-2 spike protein receptor binding. Melatonin Res 2020; 3(3): 380-416. DOI: 10.32794/mr11250069




DOI: http://dx.doi.org/10.14748/bmr.v31.7710

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About The Author

Stanislav Yanev
Institute of Neurobiology, Department of Drug Toxicology, Bulgarian Academy of Sciences, Sofia
Bulgaria

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