Trillions of bacteria, collectively referred to as the microbiota, reside in gastrointestinal tract. Helicobacter (Campylobacter) pylori (H. pylori) is an Gram negative bacillus which infects about half of the world's population. Its causative role in gastroduodenal disease is well known. Recent studies also implicated H. pylori infection in the pathobiology of autoimmune diseases such as rheumatoid arthritis and idiopathic thrombocytopenic purpura. However, little is known about H. pylori-associated alterations in metabolic pathways and food intake as related to cardiometabolic diseases such as atherosclerosis, obesity, diabetes, and metabolic syndrome. This novel approach is conceptualized as metabology of H. pylori infection. Here we Dance Round this specific topic, with special reference to possible roles played by gastric cell-secreted molecules such as leptin, ghrelin and various cytokines, collectively designated gastrokines.
Biomedical Reviews 2006; 17: 123-128.
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